Osteopontin (OPN) is involved in the regulation of vascular calcification processes. The aim of this study was to evaluate the\nrelationship between fasting serum OPN concentration and carotid-femoral pulse wave velocity (cfPWV) in geriatric persons.\nFasting blood samples were obtained from93 geriatric persons. cfPWVwere performed by SphygmoCor system. SerumOPN levels\nwere measured using a commercially available enzyme-linked immunosorbent assay. Geriatric adults who had diabetes (P = 0.007)\nor dyslipidemia (P = 0.029) had higher cfPWVlevels than those without diabetes or dyslipidemia.Theunivariable linear regression\nanalysis showed that age (P = 0.002), waist circumference (P = 0.048), body mass index (P = 0.004), systolic blood pressure\n(P= 0.001), diastolic blood pressure (P = 0.036), pulse pressure (P = 0.017), creatinine (P = 0.002), and log-OPN level (P = 0.001)\nwere positively correlated with cfPWV levels, while the high-density lipoprotein cholesterol (HDL-cholesterol) level (P = 0.007)\nand glomerular filtration rate (P = 0.001) were negatively correlated with cfPWV levels among the geriatric adults. Multivariable\nforward stepwise linear regression analysis of the significant variables also showed that log-OPN (? = 0.233, R2 = 0.123, regression\ncoefficient: 1.868, P = 0.011) was still an independent predictor of cfPWV levels in geriatric persons.
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